Occupational exposure to conventional antineoplastic drugs: can it be further limited?

The Occupational Hazards of Exposure to Antineoplastic and Chemotherapy Drugs in Nurses. A systematic review

Background: By increasing the incidence of cancer, the use of antineoplastic drugs and consequently, oncology nurses’ exposure to the drugs during daily activities has increased. Because of the importance of professional Nurses' health, the purpose of this study is to answer the question of what risks contact with antineoplastic and chemotherapy drugs in nurses?        Method: Studies on the h...

Occupational Exposure to Antineoplastic Drugs: Identification of Job Categories Potentially Exposed throughout the Hospital Medication System

OBJECTIVES Studies examining healthcare workers' exposure to antineoplastic drugs have focused on the drug preparation or drug administration areas. However, such an approach has probably underestimated the overall exposure risk as the drugs need to be delivered to the facility, transported internally and then disposed. The objective of this study is to determine whether drug contamination occu...

Preventing occupational exposures to antineoplastic drugs in health care settings.

The toxicity of antineoplastic drugs has been well known since they were introduced in the 1940s. Because most antineoplastic drugs are nonselective in their mechanism of action, they affect noncancerous as well as cancerous cells, resulting in well-documented side effects. During the 1970s, evidence came to light indicating health care workers may be at risk of harmful effects from antineoplas...

Event Abstract Comet assay as a human biomonitoring tool: application in occupational exposure to antineoplastic drugs

Occupational exposure to antineoplastic agents and parameters for renal dysfunction.

To study the nephrotoxic effects of occupational exposure to antineoplastic agents, the early renal effect parameters retinol-binding protein (RBP) and albumin (ALB) were determined in the urine of 11 hospital workers involved in the preparation and administration of antineoplastic agents and in 23 hospital workers not involved in drug handling, who served as nonexposed controls. No significant...